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(R)-Propranolol hydrochloride

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Purity:99.01%

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COA HPLC HNMR

(R)-Propranolol hydrochloride

Catalog No. T20898Cas No. 13071-11-9

(R)-Propranolol hydrochloride (Dexpropranolol hydrochloride) is the less active enantiomer of the anti-adrenoceptor (β-adrenoceptor) antagonist propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist with a high affinity for β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively.

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Pack Size	Price	Availability
25 mg	$35	In Stock
50 mg	Inquiry	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock

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Product Introduction

Bioactivity

Description	(R)-Propranolol hydrochloride (Dexpropranolol hydrochloride) is the less active enantiomer of the anti-adrenoceptor (β-adrenoceptor) antagonist propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist with a high affinity for β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively.
In vivo	Both isomers of propranolol are capable of preventing adrenaline-induced cardiac arrhythmias in cats anaesthetized with halothane and reversing ventricular tachycardia caused by ouabain in anaesthetized cats and dogs, but the dose of (-)-propranolol is significantly smaller than that of (+)-propranolol ((R)-Propranolol) in both species[4]. Administration of 10 mg/kg (R)-Propranolol hydrochloride has no antagonistic activity in rats, the cardiac responses to isoprenaline of rats can be blocked by probably much less than 1/100th of that of the (-) isomer in this preparation[4].
Alias	Dexpropranolol hydrochloride, (R)-(+)-Propranolol

Chemical Properties

Molecular Weight	295.8
Formula	C16H22ClNO2
Cas No.	13071-11-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 14.79 mg/mL (50 mM)

DMSO: 60 mg/ml (202.84 mM)

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.3807 mL	16.9033 mL	33.8066 mL	169.0331 mL
5 mM	0.6761 mL	3.3807 mL	6.7613 mL	33.8066 mL
10 mM	0.3381 mL	1.6903 mL	3.3807 mL	16.9033 mL
20 mM	0.1690 mL	0.8452 mL	1.6903 mL	8.4517 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0676 mL	0.3381 mL	0.6761 mL	3.3807 mL
100 mM	0.0338 mL	0.1690 mL	0.3381 mL	1.6903 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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